杜鑫辉      　董  扬　     杨庆诚

Langerhans cell histiocytosis (LCH) is a poorly understood disease, with different patterns of clinical presentation. There are many methods concerning the treatment of Langerhans cell histiocytosis, but the optimal choice is still to be argued. Here we present a literature review of all the papers included by WEB of KNOWLEDGE of the late 10 years on the clinical features, diagnostic methods and especially, the treatment of Langerhans cell histiocytosis. Based on the location of the lesion and clinical features, LCH can be classified into eosinophilic granuloma, Hand-Schüller-Christian disease and Letterer-Siwe disease. The symptoms vary according to the affected lesion, which can be asymptomatic or pain. LHC can affect any bone of the body, usually appearing as a radiolucent area with a sclerosis in the diaphysis or metaphysis of long bone. LHC of the spine often presents with vertebra body destruction and compression. The radiographic studies could provide evidence that indicating the diagnosis of LHC, the final decision is usually made by pathologist by studying the biopsy specimen. The treatment of LHC includes chemotherapy, radiotherapy, intralesional injection of steroids and surgery. Each method has its own indications and the treatment of patients should be individualized.