陈泉池　华莹奇　左冬青　曾辉　蔡郑东

Osteosarcoma is the most common primary malignant tumors in childhood and adolescence, and easily develops metastasis, especially in the lung. Patients with primary and metastatic tumors have a poor prognosis. Therefore, it is necessary to do some research on the genes associated with the malignancy of osteosarcoma and to find the targeted genes in the treatment of osteosarcoma. In recent years, more and more research on chemokines and chemokine receptors has been performed in oncology, which has gained increasing attention of investigators. The chemokines and chemokine receptors have been found to be important regulators in the occurrence, development and metastasis of osteosarcoma. They are thought to be active participants in the biology of osteosarcoma. Firstly, this study aims to introduce the structure, classification and biological function of chemokines and chemokine receptors. Secondly, the research progress of chemokines and chemokine receptors in oncology will be presented in 4 aspects, including the effects of chemokines and chemokine receptors on tumor growth and tumor cell survival and senescence, their effects on tumor angiogenesis, on tumor metastasis and on tumor microenvironment. At last, the research progress of chemokines and chemokine receptors in osteosarcoma will be introduced, aimed at the study of their specific targeted drugs. The current problems and future prospects of chemokines and chemokine receptors in osteosarcoma will also be clarified.